To Investigate the Highly Efficient One-Pot Synthesis of Primary Amides Catalyzed by Scandium (III) Triflate under Controlled Microwave Conditions

Abstract

There has been a recent shift in organic synthesis toward methods that are less harmful to the economy and the environment. In order to build the molecular structures, we want by connecting various organic species, new techniques have emerged as an indispensable tool, complementing more conventional ways. A model reaction using 2-aminopyridine and ethyl phenylacetate was used to optimize the reaction conditions. The parameters, including catalyst, oxidant, base, and solvent, were varied. The optimal solution was determined to be a CuI-K2CO3 mix in CH3CN subjected to visible light irradiation at room temperature. The reaction's viability was assessed by meticulously manipulating a model reaction involving isatin and (E)-3-(benzylamino)-3-(methylthio)-1-phenylprop-2-en-1-one, changing variables including catalyst, solvent, temperature, and molar concentration of the reactants. The second step was to conduct a few control tests to investigate the reaction pathways.

Keywords:  Synthesis, Primary Amides, Controlled and Mw