Pre-formulation, Studies of Multiple Unit Pellet System Aspirin Matrix Tablet

Abstract

ABSTRACT
The present work aimed preformulation studies for sustained release multi unit particulate tablet of Aspirin. Peripherally, acetylsalicylic acid acts by inhibiting the synthesis and release of prostaglandins. Migrates into the blood within 15 minutes and reaches the maximum concentration in the blood within 2.1 hours after intestinal absorption and the blood concentration half life is as short as 3.1 hours. Decreasing the dose frequency of Aspirin increases patient compliance and also improves the efficacy of contained drug, hence; hasten the cure from the indication. Therefore, MUPS tablet was prepared to control the release of Aspirin over a prolong period of time as multi unit particulate system are familiar, proven, easy to formulate and economical.
Key words: MUPS, Aspirin, Preformulation, Matrix tablet, Pelletization