IKBKE GENE-A NEWLY POTENTIAL THERAPEUTIC TARGET FOR TREATING NON-SMALL CELL LUNG CANCER

Abstract

The IKBKE gene is part of a family of enzyme complexes involved in increasing cellular inflammation. IKBKE over expression has been associated with breast and prostate cancers. However, it had not been linked to environmental carcinogen, such as tobacco smoke, until now.

Tobacco smoke is the strongest documented initiator and promoter of lung cancer. The traditional model holds that tobacco components promote carcinogenesis through a process that leads to DNA damage.

 KEY-WORDS: IKBKE, Lung cancer, Gene, Tobacco