Hepatoprotective models and screening methods: a review

Abstract

Liver, the largest organ in the body is being evolved to maintain the body’s internal milieu and also protect itself from the challenges it faces during its implementation. It is a essential organ having assorted functions. It theater a significant position not only in the metabolism, production and storage other than  in the detoxification of a lot of endogenous and exogenous compounds and converting them to less toxic substances for excretion. A number of herbal preparations are available in the market Liver cell injury caused by a range of toxic chemicals (certain chemotherapeutic agents, anti-biotic, carbon tetrachloride (CCL₄), paracetamol (PCM), thioacetamide (TAA) etc.), excessive alcohol consumption and microbes is well-studied. The present review is aimed on liver, its function, liver diseases, types of drug induced hepatotoxicity and their mechanisms of liver damage and clinical scenario.

Keywords: Hepatotoxicity, Carbon tetrachloride, Hepatoprotective, Liver injury, Paracetamol.